Progressive decrease in N-acetylaspartate/Creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury.

نویسندگان

  • S L Wootton-Gorges
  • M H Buonocore
  • R A Caltagirone
  • N Kuppermann
  • N S Glaser
چکیده

Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA.

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عنوان ژورنال:
  • AJNR. American journal of neuroradiology

دوره 31 4  شماره 

صفحات  -

تاریخ انتشار 2010